2024
- Reiner BC, Chehimi SN, Merkel R, Toikumo S, Berrettini WH, Kranzler HR, Sanchez-Roige S, Kember RL, Schmidt HD, Crist RC (2024) A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens . BioRxiv.
- Herman RJ, Schmidt HD (2024) Targeting GLP-1 receptors to reduce nicotine use disorder: preclinical and clinical evidence. Physiol Behav. PMID: 38663460.
2023
- Schmidt HD, Zhang Y, Xi J, Zanni G, Liu R, Barr GA (2023) A new formulation of dezocine, Cyc-dezocine, reduces oxycodone self-administration in female and male rats . Neuroscience Letters. PMID: 37714288.
- Caffrey A, Lavecchia E, Merkel R, Zhang Y, Chichura KS, Hayes MR, Doyle RP, Schmidt HD (2023) PYY3-36 infused systemically or directly into the VTA attenuates fentanyl seeking in male rats. Neurpharmacology. PMID: 3752954.
- Gessler CE, Decarie-Spaine L, Koh MK, Trumbauer W, Gaisinsky J, Klug ME, Pelletier C, Davis JF, Schmidt HD, Roitmann MF, Kanoski S, Hayes MR (2023) Amylin modulates VTA to mPFC circuit to suppress food intake and impulsive food-directed behavior. Biol Psychiatry. PMID: 37517705.
- Zhang Y, Ben Nathan J., Moreno A, Merkel R, Khang M, Hayes M, Reiner B, Crist R, Schmidt HD (2023) Calcitonin receptor signaling in nucleus accumbens D1R- and D2R-expressing medium spiny neurons bidirectionally alters opioid taking in male rats. Neuropsychopharmacol. PMID:37355732 .
- Herman RJ, Hayes MR, Audrain-McGovern J, Ashare RL, Schmidt HD (2023) Liraglutide attenuates nicotine self-administration as well as nicotine seeking and hyperphagia during withdrawal in male and female rats. Psychopharmacology. PMID: 37129617.
2022
- Reiner BC, Zhang Y, Stein LM, Dávila Perea E, Arauco-Shapiro G, Ben Nathan J, Ragnini K, Hayes MR, Ferraro TN, Berrettini WH, Schmidt HD, Crist RC (2022) Single nucleus transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expressed associated with volitional morphine intake. Translational Psychiatry. PMID: 36075888.
- Maurer JJ, Wimmer ME, Turner CA, Herman RJ, Zhang Y, Ragnini K, Ferrante J, Kimmey BA, Crist RC, Pierce RC, Schmidt HD (2022) Parental nicotine taking elicits heritable sex-specific phenotypes that are mediated by hippocampal Satb2. Mol Psychiatry. PMID: 35595980.
- French R, Aronowitz SC, Brooks Carthon JM, Schmidt HD, Compton P (2022) Interventions for hospitalized medical and surgical patients with opioid use disorder: A systematic review. Subst Abus. PMID: 34283698
- Best KM, Mojena MM, Barr GA, Schmidt HD, Cohen AS. Endogenous Opioid Dynorphin Is a Potential Link between Traumatic Brain Injury, Chronic Pain, and Substance Use disorder. J Neurotrauma. Jan. PMID:34751584
2021
- Merkel R, Moreno A, Zhang Y, Herman R, Ben Nathan J, Zeb S, Rahematpura S, Kamryn S, Miliken BT, Hayes MR, Doyle RP, Schmidt HD (2021) A novel approach to treating opioid use disorders: Dual agonists of glucagon-like peptide-1 receptors. Neuroscience and Biobehavioral Reviews. Oct 29. PMID: 34715149
- Axsom JE, Schmidt HD, Matura LA, Libonati JR (2021) The Influence of Epigenetic Modifications on Metabolic Changes in White Adipose Tissue and Liver and Their Potential Impact in Exercise. Front Physiol. Aug 26; 12:686270. doi: 10.3389/fphys.2021.686270.
- Zhang Y, Rahematpura S, Ragnini KH, Moreno A, Stecyk KS, Kahng MW, Miliken BT, Hayes MR, Doyle RP, Schmidt HD (2021) A novel dual agonist of glucagon-like peptide-1 receptors and neuropeptide Y2 receptors attenuates fentanyl taking and seeking in male rats. Neuropharmacology. Jul 1; 192:108599. PMID: 33965397
- French R, Aronowitz SV, Carthon JMB, Schmidt HD, Compton P (2021). Interventions for hospitalized medical and surgical patients with opioid use disorder: A systematic review. Subst Abus. Jul 20; 1-13. PMID: 34283698
- Anagarita GA, Matuskey D, Pittman B, Costeines JL, Potenza MN, Jastreboff AM, Schmidt HD, Malison RT (2021). Testing the effects of the GLP-1 receptor agonist exenatide on cocaine self-administration and subjective responses in humans with cocaine use disorder. Drug Alcohol Depend. Feb 15;221:108614. PMID: 33621809
- Aronowitz SV, Compton P, Schmidt HD (2021). Innovative Approaches to Educating Future Clinicians about Opioids, Pain, Addiction and Health Policy. Pain Manag Nurs. Aug 3;S1524-9042(20)30150-8. PMID: 32763015
- Leon RM, Borner T, Stein LM, Urrutia NA, De Jonghe BC, Schmidt HD, Hayes MR (2021). Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats. Neuropharmacology. Feb 10;187:108477. PMID: 33581143
2020
- Hernandez NS, Weir VR, Ragnini K, Merkel R, Zhang Y, Mace K, Rich MT, Pierce RC, Schmidt HD (2020) . GLP-1 receptor signaling in the laterodorsal tegmental nucleus attenuates cocaine seeking by activating GABAergic circuits that project to the VTA. Mol Psychiatry. Nov 30. PMID: 33257815
- Guerico LA, Wimmer ME, Schmidt HD, Swinford-Jackson SE, Pierce RC, Vassoler FM (2020). Deep brain stimulation of the infralimbic cortex attenuates cocaine priming-induced reinstatement of drug seeking. Nov 1;1746:147011. PMID: 32652146.
- Fortin SM, Lipsky RK, Lhamo R, Chen J, Kim E, Borner T, Schmidt HD, Hayes MR (2020). GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats. Sci Transl Med. Mar 4; 12(533).
- Turner C, De Luca M, Wolfheimer J, Hernandez NS, Madsen KL, Schmidt HD (2020). Administration of a novel high affinity PICK1 PDZ domain inhibitor attenuates cocaine seeking in rats. Neuropharmacology. Dec 2; 164.
- Zhang Y, Kahng MW, Elkind JA, Weir VR, Hernandez NS, Stein LM, Schmidt HD (2020). Activation of GLP-1 receptors attenuates oxycodone taking and seeking without compromising the antinociceptive effects of oxycodone in rats. Neuropsychopharmacology. Oct 3. PMID:31581176
2019
- Chao AM, Wadden TA, Ashare RL, Loughead J and Schmidt HD (2019). Tobacco smoking, eating behaviors, and body weight: A review. Current Addiction Reports [Epub ahead of print].
- Hernandez NS and Schmidt HD (2019). Central GLP-1 receptors: Novel molecular targets for cocaine use disorder. Physiology & Behavior. Jul 1; 206: 93-105. PMCID: PMC6520198
- Schmidt HD, Rupprecht LE and Addy NA (2019). Neurobiological and neurophysiological mechanisms underlying nicotine seeking and smoking relapse. Molecular Neuropsychiatry. Feb; 4(4): 169-189. PMCID: PMC6388439
- Hernandez NS, O’Donnovan B, Ortinski PI and Schmidt HD (2019). Activation of glucagon-like peptide-1 receptors in the nucleus accumbens attenuates cocaine seeking in rats. Addiction Biology. Mar; 24(2): 170-181. PMCID: PMC599561
- Wimmer, ME, Vassoler, FM, White, SL, Schmidt, HD, Sidoli, S, Han, Y, … & Pierce, RC. (2019). Impaired cocaine‐induced behavioral plasticity in the male offspring of cocaine‐experienced sires. European Journal of Neuroscience, 49(9), 1115-1126. PMCID: PMC6559866
2018
- Hernandez NS, Ige KY, Mietlicki-Baase EG, Molina-Castro GC, Turner CA, Hayes MR and Schmidt HD (2018). Glucagon-like peptide-1 receptor activation in the ventral tegmental area attenuates cocaine seeking in rats. Neuropsychopharmacology. Sep; 43(10): 2000-2008. PMCID: PMC6098066
- Fowler, C. D., Gipson, C. D., Kleykamp, B. A., Rupprecht, L. E., Harrell, P. T., Rees, V. W., … De Biasi, M. (2018). Basic science and public policy: Informed regulation for nicotine and tobacco products. Nicotine & Tobacco Research, published online 8/3/2017. (PMID: 29065200). 10.1093/ntr/ntx175
- Guercio, L. A., Hofmann, M. E., Swinford-Jackson, S. E., Sigman, J. S., Wimmer, M. E., Dell’Acqua, M. L., … Pierce, R. C. (2018). A-Kinase Anchoring Protein 150 (AKAP150) promotes cocaine reinstatement by increasing AMPA Receptor transmission in the accumbens shell. Neuropsychopharmacology, 43(6), 1395-1404. (PMID: 29317777). 10.1038/npp.2017.297
2017
- Van Nest, D., Hernandez, N. S., Kranzler, H. R., Pierce, R. C., & Schmidt, H. D. (2017). Effects of LY466195, a selective kainate receptor antagonist, on ethanol preference and drinking in rats. Neuroscience Letters, 639, 8-12. (PMID: 28013091; PMCID: PMC5272788). 10.1016/j.neulet.2016.12.050
- Alhadeff, A. L., Mergler, B. D., Zimmer, D. J., Turner, C. A., Reiner, D. J., Schmidt, H. D., … Hayes, M. R. (2017). Endogenous glucagon-like peptide-1 receptor signaling in the nucleus tractus solitarius is required for food intake control. Neuropsychopharmacology, 42(7), 1471-1479. (PMID: 27782127; PMCID: PMC5436110). 10.1038/npp.2016.246
- Maurer, J. J., Sandager-Nielsen, K., & Schmidt, H. D. (2017). Attenuation of nicotine taking and seeking in rats by the stoichiometry-selective alpha4beta2 nicotinic acetylcholine receptor positive allosteric modulator NS9283. Psychopharmacology(Berl), 234(3), 475-484. (PMID: 27844094). 10.1007/s00213-016-4475-7
- Hernandez, N. S., O’Donovan, B., Ortinski, P. I., & Schmidt, H. D. (2017). Activation of glucagon-like peptide-1 receptors in the nucleus accumbens attenuates cocaine seeking in rats. Addiction Biology, published online 12/11/2017. (PMID: 29226617). 10.1111/adb.12583
- Schmidt, H. D. (2017). Cocaine rearranges the neuronal epigenome. Biological Psychiatry, 82(11), 776-778. (PMID: 29110817). 10.1016/j.biopsych.2017.09.016
- Mietlicki-Baase, E. G., McGrath, L. E., Koch-Laskowski, K., Krawczyk, J., Reiner, D. J., Pham, T., … Hayes, M. R. (2017). Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior. Neuropharmacology, 123, 67-79. (PMID: 28552704). 10.1016/j.neuropharm.2017.05.024
- Reiner, D. J., Mietlicki-Baase, E. G., Olivos, D. R., McGrath, L. E., Zimmer, D. J., Koch-Laskowski, K., … Hayes, M. R. (2017). Amylin acts in the lateral dorsal tegmental nucleus to regulate energy balance through gamma-aminobutyric acid signaling. Biological Psychiatry, 82(11), 828-838. (PMID: 28237459). 10.1016/j.biopsych.2016.12.028
- Wimmer ME, Briand LA, Fant B, Guercio LA, Arreola AC, Schmidt HD, Sidoli S, Han Y, Garcia BA and Pierce RC (2017). Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny. Molecular Psychiatry. Nov; 22(11): 1641-1650. PMCID: PMC5568460
2016
- Ashare, R.L., Kimmey, B.A., Rupprecht, L.E., Bowers, M.E., Hayes, M.R., & Schmidt, H.D. (2016). Repeated administration of an acetylcholinesterase inhibitor attenuates nicotine taking in rats and smoking behavior in human smokers. Translational Psychiatry, 7(3), e1072. (PMID: 28350399; PMCID: PMC5404614).10.1038/tp.2017.46
- Schmidt HD, Mietlicki-Baase EG, Ige KY, Maurer JJ, Reiner DJ, Zimmer DJ, VanNest DS, Guercio LA, Wimmer ME, Olivos DR, DeJonghe BC and Hayes MR (2016). Glucagon-like peptide-1 receptor activation in the ventral tegmental area decreases the reinforcing efficacy of cocaine. Neuropsychopharmacology June; 41(7): 1917-1928. PMCID: PMC4869061
- Hayes MR and Schmidt HD (2016). GLP-1 influences food and drug reward. Current Opinion in Behavioral Sciences Jun; 9: 66-70. PMCID: PMC4822543
- White SL, Ortinski PI, Friedman SH, Zhang L, Neve RL, Kalb RG, Schmidt HD and Pierce RC (2016). A critical role for the GluA1 accessory protein SAP97 in cocaine seeking. Neuropsychopharmacology Feb; 41(3): 736-50. PMCID: PMC4707820
2015
- Ortinski PI, Briand LA, Pierce RC and Schmidt HD (2015). Cocaine seeking is associated with PKC-dependent reduction of excitatory signaling in accumbens shell D2 dopamine receptorexpressing neurons. Neuropharmacology May; 92: 80-9. PMCID: PMC4346508
- White SL, Vassoler FM, Schmidt HD, Pierce RC and Wimmer WE (2015). Enhanced anxiety in the male offspring of sires that self-administered cocaine. Addiction Biology Apr 29 [Epub ahead of print]. PMCID: PMC4626434
- Guercio LA, Schmidt HD and Pierce RC (2015). Deep brain stimulation of the nucleus accumbens shell attenuates cue-induced reinstatement of both cocaine and sucrose in rats. Behavioural Brain Research Mar 15; 281: 125-30. PMCID: PMC4309556
- Schmidt HD, McFarland KN, Darnell SB, Huizenga MN, Sangrey GR, Cha JH, Pierce RC and Sadri-Vakili G (2015). ADAR2-dependent GluA2 editing regulates cocaine seeking. Molecular Psychiatry Nov; 20(11): 1460-6. PMCID: PMC4412769
- Schmidt HD, Kimmey BA, Arreola AC and Pierce RC (2015). Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking. Addiction Biology Mar; 20(2): 285-96. PMCID: PMC4380181
2014
- Lee AM, Arreola AC, Kimmey BA and Schmidt HD (2014). Administration of the nicotinic acetylcholine receptor agonists ABT-089 and ABT-107 attenuates the reinstatement of nicotine-seeking behavior in rats. Behavioural Brain Research Nov 1; 274: 168-75. PMCID: PMC4179987
- Rasakham K, Schmidt HD, Kay K, Huizenga MN, Calcagno N, Pierce RC, Spires-Jones TL and Sadri-Vakili G (2014). Synapse density and dendritic complexity are reduced in the prefrontal cortex following seven days of forced abstinence from cocaine self-administration. PLoS One Jul 29; 9(7): e102524. PMCID: PMC4114454
- Ashare RL and Schmidt HD (2014). Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal. Expert Opinion on Drug Discovery Jun; 9(6): 579-94. PMCID: PMC4287224
- Kimmey BA, Rupprecht LE, Hayes MR and Schmidt HD (2014). Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and the reinstatement of nicotine seeking in rats. Addiction Biology Jul; 19(4): 539-51. PMCID: PMC3818476
2013
- Schmidt HD, Schassburger RL, Guercio LA and Pierce RC (2013). Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma. Journal of Neuroscience Aug 28; 33(35): 14160-9. PMCID: PMC3756760
- Vassoler FM, White SL, Hopkins TJ, Guercio LA, Espallergues J, Berton O, Schmidt HD and Pierce RC (2013). Deep brain stimulation of the nucleus accumbens shell attenuates cocaine reinstatement through local antidromic activation. Journal of Neuroscience Sep 4; 33(36): 14446-54. PMCID: PMC3761051
- Mietlicki-Baase EG, Rupprecht LE, Olivos DR, Zimmer DJ, Alter MD, Pierce RC, Schmidt HD and Hayes MR (2013). Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake. Neuropsychopharmacology Aug; 38(9): 1685-97. PMCID: PMC3717548
- White SL, Schmidt HD, Vassoler FM and Pierce RC (2013). Acute cocaine increases phosphorylation of CaMKII and GluA1 in the dorsolateral striatum of drug-naïve rats, but not cocaine-experienced rats. Neuroscience Letters Mar 14; 537: 71-6. PMCID: PMC3586238
- Vassoler FM, White SL, Schmidt HD, Sadri-Vakili G and Pierce RC (2013). Inheritance of a cocaine-resistance phenotype. Nature Neuroscience Jan; 16(1): 42-7. PMCID: PMC3531046
2012
- Hopkins TJ, Rupprecht LE, Hayes MR, Blendy JA and Schmidt HD (2012). Galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats. Neuropsychopharmacology Sep; 37(10): 2310-21. PMCID: PMC3422495
- Schmidt HD, Sangrey GR, Darnell SB, Schassburger RL, Cha JH, Pierce RC and Sadri-Vakili G (2012). Increased BDNF expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at Bdnf exon I-containing promoters. Journal of Neurochemistry Jan; 120(2):202-209. PMCID: PMC3243782
2011
- Schmidt HD, Shelton RC and Duman RS (2011). Functional Biomarkers of Depression: Diagnosis, Treatment and Pathophysiology. Neuropsychopharmacology Nov; 36(12): 2375-94. PMCID: PMC3194084
- Yee J, Famous KR, Hopkins TJ, McMullen MC, Pierce RC and Schmidt HD (2011). Muscarinic acetylcholine receptors in the nucleus accumbens core and shell contribute to cocaine priming-induced reinstatement of drug seeking. European Journal of Pharmacology Jan 15; 650(2-3): 596-604. PMCID: PMC3033040
- Chen YI, Famous KR, Xu H, Choi J-K, Mandeville JB, Schmidt HD, Pierce RC and Jenkins BG (2011). Cocaine self-administration leads to alterations in temporal responses to cocaine challenge in limbic and motor circuitry. European Journal of Neuroscience Vol. 34: 800-815. PMCID: PMC3172610
2010
- Sadri-Vakili G, Kumaresan V, Schmidt HD, Famous KR, Chawla P, Vassoler FM, Overland RP, Xia E, Bass CE, Terwilliger EF, Pierce RC, Cha JH (2010). Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine. Journal of Neuroscience Sep 1; 30(35): 11735-44. PMCID: PMC2943400
- Schmidt HD and Duman RS (2010). Peripheral BDNF produces antidepressant-like behavioral and cellular responses. Neuropsychopharmacology Nov; 35(12): 2378-91. PMCID: PMC2966759
- Duric V, Banasr M, Licznerski P, Schmidt HD, Simen A, Newton SS, Stockmeier C and Duman RS (2010). MAP kinase phosphatase 1 (MKP-1) alters behavior in a rodent model of depression. Nature Medicine Nov; 16(11): 1328-32. PMCID: PMC3066515
- Schmidt HD and Pierce RC (2010). Cocaine-induced neuroadaptations in glutamate transmission: Potential therapeutic targets for craving and addiction. Annals of the NY Academy of Sciences; Addiction Reviews 2, Feb. 1187: 35-75.
2009
2008
- Schmidt HD, Banasr M, and Duman RS (2008). Future antidepressant targets: neurotrophic factors and related signaling cascades. Drug Discovery Today: Therapeutic Strategies 5(3): 151-6. PMCID: PMC2739451
- Famous KR, Kumaresan V, Sadri-Vakili G, Schmidt HD, Mierke DF, Cha J-HJ and Pierce RC (2008). Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking. Journal of Neuroscience 28: 11061-11070. PMCID: PMC2601563
- Vassoler FM, Schmidt HD, Gerard ME, Famous KR, Ciraulo DA, Kornetsky C, Knapp CM and Pierce RC (2008). Deep brain stimulation of the nucleus accumbens shell attenuatescocaine priming-induced reinstatement of drug seeking in rats. Journal of Neuroscience 28: 11061-11070. PMCID: PMC2585378
2007
2006
- Schmidt HD and Pierce RC (2006). Systemic administration of a dopamine, but not a serotonin or norepinephrine, transporter inhibitor reinstates cocaine seeking in the rat. Behavioral Brain Research 175: 189-194.
- Schmidt HD and Pierce RC (2006). Cooperative activation of D1-like and D2-like dopamine receptors in the nucleus accumbens shell is required for the reinstatement of cocaine-seeking behavior in the rat. Neuroscience 142: 451-461.
- Schmidt HD, Anderson SM and Pierce RC (2006). Stimulation of D1-like or D2 dopamine receptors in the shell, but not the core, of the nucleus accumbens reinstates cocaine-seeking behavior in the rat. European Journal of Neuroscience 23: 219-228.
- Howe ML, Mehmud ZF, Saha S, Buratovich M, Stutius EA, Schmidt HD, Lenon AL, Reddicks C, Ivanov GS, Przyborski SA and Ozer JS (2006). Transcription factor IIA t is associated with undifferentiated cells and its gene expression is repressed in primary neurons at the chromatin level in vivo. Stem Cells and Dev. Apr; 15(2): 175-90.
- Anderson SM, Schmidt HD and Pierce RC (2006). Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking. Neuropsychopharmacology 31: 1452-1461.
2005
2004
