The high rates of relapse associated with current medications used to treat opioid use disorder (OUD) necessitate research that expands our understanding of the neural mechanisms regulating opioid taking to identify molecular substrates that could be targeted by novel pharmacotherapies … Read More
Nicotine cessation is associated with increased consumption of highly palatable foods and body weight gain in most smokers. Concerns about body weight gain are a major barrier to maintaining long-term smoking abstinence, and current treatments for nicotine use disorder (NUD) … Read More
Nicotine intake, whether through tobacco smoking or e-cigarettes, remains a global health concern. An emerging preclinical literature indicates that parental nicotine exposure produces behavioral, physiological, and molecular changes in subsequent generations. However, the heritable effects of voluntary parental … Read More
Opioid exposure is known to cause transcriptomic changes in the nucleus accumbens (NAc). However, no studies to date have investigated cell type-specific transcriptomic changes associated with volitional opioid taking. Here, we use single nucleus RNA sequencing (snRNAseq) to comprehensively characterize … Read More
Schmidt Lab members Dr. Yanfang Zhang, Suditi Rahematpura, Kael Ragnini, Amanda Moreno, Kamryn Stecyk and Michelle Kahng, along with collaborators Dr. Brandon Milliken, Dr. Matthew Hayes, and Dr. Robert Doyle, recently published a paper in Neuropharmacology. Find the abstract below: … Read More
Schmidt Lab members Dr. Nicole Hernandez, Kael Ragnini, Riley Merkel, Dr. Yafang Zhang and lab alumnae Vanessa Weir and Kyla Mace recently published a paper in Molecular Psychiatry. Find the abstract below: An emerging preclinical literature suggests that targeting central … Read More
Schmidt Lab alumni Christopher Turner, Jordan Wolfheimer, and Dr. Nicole Hernandez, in collaboration with Drs. De Luca and Madsen of the University of Copenhagen, recently published a paper in Neuropharmacology . Find the abstract below: Protein interacting with C kinase-1 … Read More
Postdoctoral researcher Yafang Zhang recently had a paper published in Neuropsychopharmacology in collaboration with many of our lab members! Congrats Yafang! Find the abstract below: Despite the effectiveness of current medications to treat opioid use disorder, there is still a … Read More